NASP modulates histone turnover to drive PARP inhibitor resistance

www.nature.com

NASP modulates histone turnover to drive PARP inhibitor resistance

www.nature.com

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NatureEnglish · 20 days ago

Nature, Published online: 13 August 2025; doi:10.1038/s41586-025-09414-z

PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

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