Fitoterapia. 2025 Aug 14:106824. doi: 10.1016/j.fitote.2025.106824. Online ahead of print.

ABSTRACT

Tamarindus indica and Colocasia esculenta are two highly popular edible plants known for their multiple biological activities and diverse secondary metabolites. The aim of this study was to explore the obesity management potential of the leaf extracts of both plants through in-vitro, in-vivo and in silico studies. T. indica leaf ethanol extract (TLEE) was standardized by High Performance Liquid Chromatograph (HPLC) to contain 6.8 μg/mL luteolin, whereas C. esculenta leaf ethanol extract (CLEE) was standardized to contain 3.1 μg/mL luteolin. In-vitro anti-inflammatory response in adipose tissue was analyzed by 15-lipoxygenase inhibition, the combined sample of TLEE and CLEE exhibited the highest inhibition at each concentration, reaching over 80 % at 1000 μg/mL concentration showing statistically significant** (P < 0.01) results. An in vivo anti-obesity in-vivo study was performed using a high-fat and high-sucrose diet on letrozole-induced obesity in 55 female Wistar albino rats divided into 11 groups for a 90-day treatment protocol. Results revealed that a combined dose of TLEE 200 mg/kg and CLEE 500 mg/kg led to significant *** P < 0.001 reductions in BMI (1.25 ± 0.03 to 0.66 ± 0.01), and lipid profiles without inducing ketosis. They also ameliorated both the liver and renal function tests. Molecular docking of luteolin with 15-lipoxygenase demonstrated a binding affinity of > - 8 kcal/mol, suggesting strong inhibitory potential; thus, this research offers a promising, non-ketogenic strategy for obesity management. The synergistic effect of Tamarindus indica and Colocasia esculenta extracts can be used to develop cost-effective treatments for human obesity.

PMID:40818783 | DOI:10.1016/j.fitote.2025.106824

From ketogenic via this RSS feed