Ketogenic Diet as Protection for Deprescribing Antipsychotics - PubMed
pubmed.ncbi.nlm.nih.gov
People with schizophrenia or schizoaffective disorder are almost always treated with continued use of antipsychotics. Tapering of antipsychotics is very often associated with a recurrence of symptoms within a year. This applies particularly to the final steps of reduction from very small doses. Keto …

Schizophr Bull. 2025 Aug 23:sbaf127. doi: 10.1093/schbul/sbaf127. Online ahead of print.

ABSTRACT

People with schizophrenia or schizoaffective disorder are almost always treated with continued use of antipsychotics. Tapering of antipsychotics is very often associated with a recurrence of symptoms within a year. This applies particularly to the final steps of reduction from very small doses. Ketosis seems to offer protection against psychotic relapses in these final steps. I report a case series that supports this thesis. Two effects of antipsychotics that disappear after discontinuation of the medication and can be replaced by ketosis could possibly be responsible for this: effects on the mesolimbic system against the background of insufficient GABAergic inhibition in the prefrontal cortex and mesolimbic system; effects on the microglia against the background of increased unspecific neuroinflammation.

PMID:40849111 | DOI:10.1093/schbul/sbaf127

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