PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia

www.nature.com

PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia

www.nature.com

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NatureEnglish · 9 days ago

Nature, Published online: 03 September 2025; doi:10.1038/s41586-025-09486-x

A PICALM allele associated with increased risk of late-onset Alzheimer’s disease has a microglial-specific role in lipid droplet accumulation.

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