Programmable antisense oligomers for phage functional genomics

www.nature.com

Programmable antisense oligomers for phage functional genomics

www.nature.com

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NatureEnglish · 4 hours ago

Nature, Published online: 10 September 2025; doi:10.1038/s41586-025-09499-6

Establishing antisense oligomers as versatile, non-genetic tools to silence phage mRNAs opens applications in basic research and biotechnology, as shown by identifying essential factors for propagation of the nucleus-forming jumbo phage ΦKZ such as the RNase H-like protein ΦKZ155.

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