Nature, Published online: 17 September 2025; doi:10.1038/d41586-025-02962-4

Organelles called peroxisomes have been found to have a role in heat generation in fat tissue, and use a mechanism independent of the known heat-producing protein UCP1. The process involves the synthesis and degradation of monomethyl branched-chain fatty acids, driven by the lipid-synthesizing enzyme FASN and the peroxisomal enzyme ACOX2.

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