Peroxisomal metabolism of branched fatty acids regulates energy homeostasis

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Peroxisomal metabolism of branched fatty acids regulates energy homeostasis

www.nature.com

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NatureEnglish · 5 days ago

Nature, Published online: 17 September 2025; doi:10.1038/s41586-025-09517-7

A UCP1-independent mechanism of thermogenesis involving ATP-consuming metabolism of monomethyl branched-chain fatty acids in peroxisomes is described and a previously unrecognized role for peroxisomes in adipose tissue thermogenesis is identified.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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