Nature, Published online: 17 September 2025; doi:10.1038/s41586-025-09545-3

Cryo-electron microscopy was used to study human mechanistic target of rapamycin complex 1 (mTORC1) activation on lysosomal membranes, showing progressive recruitment by RAG–Ragulator, RHEB and RAPTOR, culminating in mTOR–membrane engagement and full enzyme activation.

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