Nature, Published online: 24 September 2025; doi:10.1038/d41586-025-03067-8

The temporal evolution of a hidden, low-dimensional and organism-wide process, inferred from measuring the pupil of an eye, has been shown to account for complex spatio-temporal patterns of brain activity over timescales of seconds. This points to an underlying dynamic that continuously structures the unfolding of brain, body and behavioural variables.

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