In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma

www.nature.com

In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma

www.nature.com

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NatureEnglish · 3 days ago

Nature, Published online: 24 September 2025; doi:10.1038/s41586-025-09489-8

In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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