Reprogramming neuroblastoma by diet-enhanced polyamine depletion

www.nature.com

Reprogramming neuroblastoma by diet-enhanced polyamine depletion

www.nature.com

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NatureEnglish · 1 day ago

Nature, Published online: 24 September 2025; doi:10.1038/s41586-025-09564-0

Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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