SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer

www.nature.com

SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer

www.nature.com

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NatureEnglish · 3 days ago

Nature, Published online: 24 September 2025; doi:10.1038/s41586-025-09574-y

Mutual paracrine regulation of the cytokines GREM1 and SPP1 mediate mesenchymal and epithelial cell fate in pancreatic cancer.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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