Nutr Hosp. 2025 Sep 17. doi: 10.20960/nh.05901. Online ahead of print.

ABSTRACT

INTRODUCTION: the effectiveness of the ketogenic diet (KD) as a therapeutic approach for managing weight, hormonal, and metabolic aspects of polycystic ovary syndrome (PCOS) requires further clarification despite its growing popularity.

OBJECTIVES: this study evaluated the short-term effects of a 4-week low-calorie ketogenic diet (LCKD) on body composition, biochemical, and hormonal parameters in overweight or obese women with PCOS.

METHODS: thirteen women with PCOS (mean age 29.77 ± 7.54 years, median BMI 27.2 kg/m²) participated in this clinical intervention study. Body composition (bio-electrical impedance), anthropometric measurements, and biochemical/hormonal parameters were assessed pre- and post-intervention.

RESULTS: participants achieved a mean body weight loss of 6.90 % ± 2.04 %. Significant reductions were observed in body weight, BMI, fat percentage, fat mass, fat-free mass, waist, hip, and neck circumferences, and waist-to-hip/waist-to-height ratios (p < 0.05). LCKD also led to significant decreases in fasting glucose, insulin, HOMA-IR, HDL-cholesterol, prolactin, and IGF-1 levels (p < 0.05). Conversely, SHBG and TNF-α levels significantly increased (p < 0.05). Multiple regression analysis indicated that changes in waist (t = 4.196), hip (t = 3.983), and neck (t = -2.820) circumferences significantly impacted prolactin levels, while changes in fat percentage (t = -3.326, p = 0.021), fat mass (t = 3.501, p = 0.017), and hip circumference (t = 2.905, p = 0.034) influenced SHBG levels (p < 0.05).

CONCLUSIONS: short-term LCKD intervention shows potential as a therapeutic dietary strategy, yielding beneficial effects on both anthropometric and key biochemical parameters in overweight or obese women with PCOS.

PMID:41021353 | DOI:10.20960/nh.05901

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