Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis

www.nature.com

Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis

www.nature.com

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NatureEnglish · 1 day ago

Nature, Published online: 01 October 2025; doi:10.1038/s41586-025-09588-6

An analysis of T cell responses in people with amyotrophic lateral sclerosis shows that the C9orf72 antigen is a key target of autoimmune responses in the disease, and identifies C9orf72 epitopes that are recognized.

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