KCTD10 is a sensor for co-directional transcription–replication conflicts

www.nature.com

KCTD10 is a sensor for co-directional transcription–replication conflicts

www.nature.com

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NatureEnglish · 4 days ago

Nature, Published online: 08 October 2025; doi:10.1038/s41586-025-09585-9

KCTD10 interacts with the DNA replication machinery and the RNA polymerase complex, inducing ubiquitination and removal of the transcription machinery in the event of co-directional transcription–replication conflicts.

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