Sex and smoking bias in the selection of somatic mutations in human bladder

www.nature.com

Sex and smoking bias in the selection of somatic mutations in human bladder

www.nature.com

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NatureEnglish · 19 hours ago

Nature, Published online: 08 October 2025; doi:10.1038/s41586-025-09521-x

Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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