Sperm sequencing reveals extensive positive selection in the male germline

www.nature.com

Sperm sequencing reveals extensive positive selection in the male germline

www.nature.com

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NatureEnglish · 6 days ago

Nature, Published online: 08 October 2025; doi:10.1038/s41586-025-09448-3

A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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