Nature, Published online: 15 October 2025; doi:10.1038/d41586-025-03327-7

Almost-complete genomes of more than 1,000 strains of the single-celled yeast species Saccharomyces cerevisiae have been assembled and integrated with phenotypic (trait) measures of growth and of RNA and protein expression. The analysis shows how large genomic variations called structural variants disproportionately shape traits.

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