Nature, Published online: 15 October 2025; doi:10.1038/s41586-025-09624-5

G2E3-catalysed H3K14 mono-ubiquitination is crucial for SUV39H compartmentalization and H3K9 trimethylation in pericentromeric heterochromatin, which is essential for proper euchromatin organization and transcriptional regulation in mammalian cells.

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