NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity

www.nature.com

NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity

www.nature.com

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NatureEnglish · 1 month ago

Nature, Published online: 23 July 2025; doi:10.1038/s41586-025-09303-5

An NNMT inhibitor reduces tumour burden and metastasis in multiple mouse cancer models and restores immune checkpoint blockade efficacy by decreasing cancer-associated-fibroblast-mediated recruitment of myeloid-derived suppressor cells and reinvigorating CD8+ T cell activation.

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