Nanobody therapy rescues behavioural deficits of NMDA receptor hypofunction

www.nature.com

Nanobody therapy rescues behavioural deficits of NMDA receptor hypofunction

www.nature.com

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NatureEnglish · 1 month ago

Nature, Published online: 23 July 2025; doi:10.1038/s41586-025-09265-8

A bivalent biparatopic nanobody penetrates the brain, binds to and potentiates the activity of homodimeric metabotropic glutamate receptor 2, correcting cognitive deficits in two preclinical mouse models with endophenotypes resulting from NMDA receptor hypofunction.

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